Comparison of the effects of sesame butter and sesame oil intake on serum glucose levels and lipid profiles on diabetic rats

Background and Diabetes is one of the most common endocrine metabolic disorders, resulting from defects in insulin secretion, insulin action, or both. According to the useful properties of sesame and extensive use of its products (like sesame butter) in Khuzestan province, the purpose of this study was to investigate the effects of sesame butter vs. sesame oil on serum glucose levels and lipid profiles on diabetic rats. Forty male rats of Wistar Strain were randomly divided into 4 groups (10 rats per group) and were being treated for 6 weeks as follows: Group 1: non diabetic control rats; Group 2: diabetic control rats; Group 3: diabetic rats that were being treated with 1.25 g/kg sesame butter; and Group 4: diabetic rats that were being treated with 0.5 g/kg sesame oil. At the end of the experimental period, serum levels of glucose and lipid profiles were measured. The statistical analysis was carried out, using SPSS 18 software. One way analysis of variance (ANOVA) and Independent sample test were used to compare means between the treated and controlled groups. P< 0.05 was considered as significant. Utilization of sesame butter and sesame oil in diabetic rats's regime caused a significant decrease in glucose concentrations and also led to increase in high density lipoprotein-c levels compared to the diabetic control rats (P<0.05). Triglyceride levels were also decreased after 6 weeks in the sesame oil treated diabetic group (P=0.000). The results of presented study indicate the improving effects of sesame butter and sesame oil on controlling glucose levels and lipid profiles in the animal models of diabetes.