Effects of hydroalcholic and chloroformic extracts of Salvia Candidissima on hyperalgesia and edema during adjuvant-induced arthritis

Inflammatory sympotoms such as edema and hyperalgesia were induced by some mediators like cytokines in response to irritant stimulus. The aim of this study was to investigate the effects of hydroalcholic and chloroformic extracts of Salvia Candidissima on hyperalgesia and edema during adjuvant-induced arthritis in rats. Inflammation was induced by ingle sabcutaneous injection of CFA to rat hindpaw. Hydroalcholic and chloroformic extracts of Salvia Candidissima prepared from aerial part of plant and different dose of extracts (25, 50 and 100/kg) were administrated (i.p.) during the 7-day study. Indomethacin (5 mg/kg) used as positive control. Hyperalgesia and edema were assessed at 0, 3 and 7 days after artrithit induction by CFA by radiant heat and plethysomometer, respectively. The result showed that hydroalcholic and chloroformic extacts of Salvia Candidissima at dose of 50 mg/kg caused significant reduction in hyperalgesia and edema on days 3 and 7 as compared with the day zero, negative control and positive control (receiving indomethacin at dose of 5 mg/kg, daily) groups (p<0.001). It can be concluded that hydroalcholic and chloroformic extracts of Salvia Candidissima dose dependently reduce edema and hyperalgesia during CFA-induced inflammation.