The Tratogenic Effect of Antidepressant Drug, Imipramine Hydrochloride on the Embryos of NMRI Mice

Imipramine hydrochloride is an antidepressant drug used widely for the treatment of depression and anxiety. Action is via inhibition of uptake of serotonin and nor epinephrine at presynaptic nerve terminals. Several malformations in human, mainly neural tube defects, reduction growth, increase of embryo resorbtion and increase of seizure and mother death. Results show that with increase of dose mean crown – rump and weight of the fetuses in three experimental groups were significantly reduced compared with those of the control groups. Furthermore mean of embryo resorbtion were significantly increase compared with control group.