Large cell calcifying Sertoli cell tumor(LCCSCT): a case report

A 25-year-old man referred to our urologist with chief complaint of right testicular pain ofone month duration. Ultrasonography of the testis was performed two times within eight days.The results of ultrasound showed a tumor in the lower pole of the right testicle. In the first ultrasound, tumor size was 7 mm and in the second one it was 7.6 mm. Tumor markers were measured which showed normal alpha-fetoprotein and beta HCG levels. Right orchiectomy was performed.Histological analysis showed that the tumor was consisted of neoplastic cells with eosinophilic cytoplasm and round nuclei, fibrotic stroma and calcific bodies. The incidence of testicular tumors is only 5 cases per 100,000 men; and less than one percent of testicular tumors are related to Sertoli cells. The results of a review study showed that only 61 cases of large cell calcifying Sertoli cell tumor have been reported until 2005. This tumor can produce estrogen which leads to breast enlargement,sexual impotence and acromegaly in men. However, examinations revealed that our patient did not have any of these problems. In most cases this tumor occurs in childhood and patients younger than 20 years of age, but our patient was 25-year-old. LCCSCT is a rare sex cord-stromal tumor with a low malignant potential. A favorable prognosis can be achieved with radical orchiectomy.