Evaluation of the effect of dexmedetomidine on post-operative pain in patients undergoing gynecologic diagnostic laparoscopy

Dexmedetomidine provides postoperative analgesia without any effect on respiration. This prospective، randomized، double-blind study was designed to evaluate postoperative effects of dexmedetomidine on postoperative analgesia and sedation in outpatient gynecologic diagnostic laparoscopy under general anesthesia.

57 infertile patients (ASA physical status I and II) scheduled for outpatient gynecologic diagnostic laparoscopy were randomly allocated into two groups، dexmedetomidine group (D group، n = 28)، or control group (C group، n = 29). In D groupe، dexmedetomidine 1μ g/Kg was used during induction time and then 0. 5μ/kg/hr until the end of surgery and in C group normal saline was infused.

No significant diffrence were observed in MAP،VAS and sedation. Heart rate were lower in induction time and at 15 min after that (p<0. 008) & (p<0. 04). The D groupe needed lower doses of morphine in the postoperative period (0. 3±0. 9 vs 1. 0±1/2) (p<0. 02).

The present study demonstrates that intravenous infusion of 1μg/Kg of dexmedetomidine during induction and 0. 5μg/Kg/hr as maintenance provided better analgesia in the postoperative period without delayed discharge and provided perioperative hemodynamic stability during gynecologic diagnostic laparoscopy. Dexmedetomidine by decreasing pain may increase satisfaction of patients.