Effectiveness of platelet-rich plasma (PRP) application on Improvement of physical
Message:
Abstract:
Background
In recent years platelet rich plasma (PRP) has been receiving growing attention in treatment of soft –tissue injuries and lots of studies have been undertaken in many files such as sport medicine and orthopedic surgery (treatment of chronic tendinopathy), but there is limited well design randomize control trails in this filed. To shed some light on these controversies we conducted a systematic review and metaanalysis to determine the efficacy of PRP on the improvement of physical function in athletes.
Method
We searched Pub Med, Cochrane Database of Systematic Reviews, DARE Database, Elsevier, EMBASE, and Wiley Online Library for randomized controlled trials that studied on application of PRP on athletes, sport medicine or orthopedic fields. Further, we did additional searches by reference checking through the bibliographies of eligible studies, contacting with authors, assessing grey literatures.
Results
The search retrieved 905 articles, from which 5 randomized control trials met our inclusion criteria for systematic review and meta-analysis. The quantitative analysis of physical activity/function, by VISA score; (Victorian Institute of Sport Assessment) showed that PRP is not more effective than other comparators.
Conclusions
These Meta-analyze prove no more effectiveness for application of PRP in sport related injuries. Further well design RCTs are needed to support these findings. According to lack of strong evidence to support the effectiveness of PRP, increasing clinical use of platelet-rich plasma for sport related injuries should be limited.
Language:
Persian
Published:
Teb va Tazkiyeh, Volume:23 Issue:3, 2015
Pages:
21 - 32
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