Study on liver histopathological changes of Gold fish (Carassius auratus) during exposure to lethal and sub lethal concentrations of cadmium

The aim of current study was to evaluate the effects of heavy metal cadmium on liver tissue of gold fish during experimental condition. Study was in a week on 5 treatments and 3 replicates، five concentration (2. 8، 5. 6، 8. 4 and 11. 2 ppm respectively) of cadmium as 0 (control)، 25%، 50%، 75% and 100% of LC50 were selected and tested. Histopathological changes were done using classic histology method in hematoxylin and eosin staining and using a light microscope and camera images properly installed and connected the camera to the computer system software was developed. The overall result of this study showed that in liver tissue exposed to cadmium over a week with increasing duration of exposure to pesticide exposure، a high level of toxin in the lesion by the most frequent lesions end of a week، was observed including necrosis، atrophy and cloudy swelling of the cell. Result of this study show that liver tissue have many lesions in response to cadmium in one week and it will be increase with concentration and duration of toxin، as it was seen highest amount of lesions at the end of experiment within last dose.