Hormone therapy after menopause: Advantages and Disadvantages

Hormone therapy is widely used to control the menopause symptoms، prevention and treatment of cardiovascular disease، osteoporosis and dementia in old women. This study was performed with aim to identify the long-term effects of hormone therapy on menopausal problems. This study was performed as a review of 25 articles related to hormone therapy after menopause between 1999 and 2010. Searching was performed in databases including ISI web of Science، Up to date، and Scopus using keywords of menopause، hormone therapy، complications of hormone therapy، estrogen and progesterone. Inclusion criteria included the insertion of search terms in the title or keywords of the article. Articles with incomplete data and articles which only their abstracts are available were excluded. In relatively healthy women، continuous combined hormone therapy significantly increases the risk of venous thromboembolism or coronary events، stroke، breast cancer and gallbladder disease. Long-term hormone therapy with estrogen alone significantly increases the risk of stroke and gallbladder disease. In general، the only benefits of hormone therapy are reducing the incidence of fractures and colon cancer with long-term use. Hormone therapy is not an indication for routine management of chronic disease. There is a need for more evidence on the safety of hormone therapy to control the menopausal symptoms. It is believed that short-term use of hormones is relatively safe for healthy younger women.