Antibacterial Activity of Methanol Extracts from Different Parts of Prangos crossoptera and their Synergistic Effect on Some Antibiotics

Background and Resistance to antibiotics has decreases the performance of antibiotics and has dramatically increased over the past few years. This has led to increasing interest towards discovery and introduction of new antibiotic compounds, especially plant-derived compounds. The aim of this study was to investigate the antibacterial activity of the methanol extracts from different parts of Prangos crossoptera against pathogenic bacteria and their drug synergistic and antagonistic with standard antibiotics. Antibacterial activity of methanol extracts from different parts of Prangos crossoptera was investigated against Proteus mirabilis, Proteus vulgaris, Streptococcus sobrinus, and Staphylococcus saprophyticus in 250 to 3000 µg/ml concentrations by disc diffusion and micro-broth dilution methods. Then, the MIC and MBC values and inhibition zone of all extracts were measured. The synergistic effects of the most efficient concentration were studied on four common antibiotics. All tested extracts, especially the flower, exhibited significant antibacterial activity against studied bacteria. The flower extract also showed synergistic effect on penicillin and ampicillin activity but did not influence the performance of gentamicin and streptomycin. The P.crossoptera has significant antibacterial effect and could increase the activity of penicillin and ampicillin.