Evaluation of Anti tumor properties of indoloquinazoline on MCF-7 cell line

Aim and Chemotherapy is a category of cancer treatment that uses chemical agents. The harmfulness of chemotherapy on normal cells by killing cells is the most common side-effects of chemotherapy. Characterization and selection of new powerful chemotherapy agents which have low side effects are important. Indoloquinazoline has a variety of biological activities such as antimicrobial activities and cytotoxic properties. In this study, cytotoxic effect of synthetic indoloquinazoline compound was studied on breast cancer cell line and compared with cisplatin. Anti tumor activity of indoloquinazoline compound and cisplatin was studied on breast cancer cell line, MCF-7, by MTT assay. Indoloquinazoline compound showed antitumor activity with IC50 of 6.83 µg/ml by being Compared with 39.13 µg/ml of cisplatin, as a kind of standard drug on MCF-7 cell line. The results showed indoloquinazoline is cytotoxic more than cisplatin on MCF-7 cell line.