Effect of green tea extract (Camellia sinensis) on kidney toxicity induced by sodium arsenite: a stereological study
Author(s):
Abstract:
Background And Objective
Sodium Arsenite is an environmental pollutant which can generate free radicals causing tissue damage. This study was done to evaluate the effect of Green Tea (GTE), as a strong antioxidant, on kidney tissue in mice treated with Sodium Arsenite.Methods
In this experimental study 24 adult male NMRI mice were randomly allocated into four groups including: control, GTE (100mg/kg/day), Sodium Arsenite (5mg/kg/day) and Sodium Arsenite GTE, for 34 days, orally. Animals were scarified and left kidney was taken out, fixed, sectioned, processed and stained using Heidenhainazan method. Using stereological technique the total volume of kidney, volume of cortex, medulla, proximal and distal tubule, renal corpuscle, gelomerelus, tuft and capillary, membrane and space of Bowman's capsule and length of proximal and distal tubule were determined. Creatinine, BUN and MDA serum samples were measured.Results
The mean of total volume of cortex, proximal tubule, distal tubule, renal corpuscle and gelomerolus, taft, Bowman's capsule space, size of epithelium and lumen of proximal and distal tubule were significantly reduced in Sodium Arsenite group compared to control (PConclusion
Green tea has a protective role in Sodium Arsenite induced nephrotoxicity. Keywords:
Kidney , Green Tea , Sodium Arsenite , Stereology , Mouse
Language:
Persian
Published:
Journal of Gorgan University of Medical Sciences, Volume:18 Issue: 1, 2016
Pages:
30 to 38
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