Effects of  Metformin on serum glucose, lipid profiles and oxidative stress in the alloxan-induced diabetic rats

The diabetes type 2 is the most common and growing issue of the world health. The purpose of this study is to evaluate the effects of “Metformin” on glucose, lipid profiles and oxidative stress in the alloxan-induced diabetic rats. In this study 40 Wistar rats, were randomly separated into 4 equal groups, containing: healthy control group, diabetic group, metformin-controlled group, and diabetic rats treated with metformin. Diabetes was induced by single dose of intraperitoneal injection of 120 mg/kg Alloxan. The groups 3 and 4 were fed 150 mg/kg/day of metformin for a period of one month. At the end, blood of all the rats were collected and the serum levels of glucose, triglycerides, cholesterol, LDL, HDL, VLDL, lipid peroxidation products as malondialdehyde index, plus the superoxide dismutase enzymes, glutathione peroxidase, catalase and total antioxidant in blood were measured. Finally, the quantitative data obtainedwere analyzed by ANOVA and Tukey’s post test amongst the groups at p