A comparison of the effect of Carumcarvi L. vs. Mefenamic acid on Ibuprofen use on after pains

After pains are painful contractions of the uterus occurring after delivery. According to the side effects of NSAIDs to assess the efficacy of Carumcarvi L. vs. Mefenamic acid on the severity of after pains in postpartum this study was done in Laretsan university affiliated hospital in 2013.
In a double-blind randomized clinical trial, 102 hospitalized women who complained of moderate to severe after pains, after uncomplicated spontaneous vaginal delivery, were treated with oral doses of Carumcarvi L. 615 mg, Mefenamic acid 250 mg or placebo. Pain ratings were recorded before the first dose and at 0.5, 1, 2, 3, 4, 5 and 6 hours after the first dose on a 0-10 numeric pain intensity scale. Thereafter every six hours, pain rating was recorded and if the patient required analgesic after 30 minute, pain rating was recorded again. If the pain will not relieve, a 200-mg ibuprofen tablets was administered to the patient. The number of ibuprofen tablets consumed during the intervention was compared between three groups. The data was analyzed by ANOVA, kruskal-wallis and chisquare test.
In first six hours ibuprofen consumption in placebo group (75.8%) was more than caraway group (45.7%) and mefenamic acid group (35. 3%) (p=0. 003). 72 hours after delivery the mean number of ibuprofen consumption after intervention showed statistically significant differences between three groups (placebo 4.0±3.04, caraway 3.66±3.271 and mefenamic acid 1.76±2.948) (p=0. 000). There were no significant difference between caraway and placebo (p=0.51). In mefenamic acid group the analgesic use was less than Caraway, and Placebo groups (p=0.001).
This study showed that Caraway can reduce the need for chemical analgesics.