The Analgesic Effect of Echinophora Platyloba Hydroalcoholic Extract in Male Rats

In traditional Iranian medicine, use of medicinal herbs is prevalent for the treatment and alleviation of pain and inflammation. Echinophora Platyloba is one of the major medicinal herbs with confirmed anti-cancer, anti-microbial, and anti-fungal effects. Therefore, in this study, we aimed to evaluate the analgesic effects of E. platyloba hydroalcoholic extracts in male rats.
In this experimental study, 42 rats were divided into six groups, i.e., control group, extract groups (80, 100, and 300 mg/kg via intraperitoneal injection), morphine group (1 mg/kg via intraperitoneal injection), and naloxone group (1 mg/kg of naloxone along with 300 mg/kg of the extract). To evaluate the analgesic effects of the extracts, rating, tail flick, and formalin tests were performed.
FINDINGS: In the writhing test, doses of 100 and 300 mg/kg of the extracts could decrease the rating score from 43.3±22.61 to 27.31±2.34 (p According to the present results, E. platyloba hydroalcoholic extracts have central and peripheral analgesic effects.