Association Between Vitamin D and Gestational Diabetes

Vitamin D deficiency is the most common nutritional deficiency as well as a basic factor for normal bone growth. Increasing evidence indicates that the vitamin D contributes to normal glucose homeostasis and its deficiency is associated with impaired insulin secretion, as demonstrated in some reported studies. However, very limited studies and some even with conflicting results, have addressed the association between the level of 25-hydroxyvitamin D in circulation and the risk of gestational diabetes.
Objevtives: Investigating the association between vit D deficiency and gestational diabetese.
This case-control study was conducted on 157 women aged 15-50 years, referred to Rasht alzahra Hospital. Demographic data and medical history were collected. In doing so, for evaluation of gestational diabetes, glucose challenge test was done. Also, vitamin D level measurement was performed using Diasorin kit and CLIA method and the obtained results were analyzed by SPSS version 16.
The mean age of the normal group was 26.75± 4.96 and the mean age for those with gestational diabetese was 27.07± 5.73 .( p = 0.7) .BMI index was the same for both groups and the average vitamin D serum levels for normal and patient groups were 11.06±17.81 and 17.41±6.76 nmol/l , respectively. Using regression logistic model, we demonstrated that increasing vitamin D serum level can reduce the chance of gestational diabetese by 5%. OR=0.95 (CI=0.91-0.99)
In conclusion, gestational diabetese and vitamin D level seem to be negatively correlated. (P=0.002)