Histopathological Examination of Oralmedic Effects on Oral Wound Healing Process: an Animal Study

Recurrent aphthous stomatitis (RAS) is a common disease and suitable treatment has been unsuccessful. The purpose of this study was evaluating oral wound healing process following use of Oralmedic.
In this animal study, mucosal ulcers with the same size were made in the lower lip of 12 mice with the same weight, gender and race. The mice were selected randomly divided into two groups of six mice each, oralmedic and distilled groups. The Oralmedic has been used on the wound in the first group and distilled water was applied on the wound in the second group twice a day for 5 days. On the fifteenth day, biopsy was obtained from wound healing areas and they were investigated through microscopic examination.
The epithelium in the restored areas in both two groups was almost normal (p>0.05). In the studied groups, oral medic created different inflammatory effects in the connective tissues. In terms of medicine, formation of the granulation tissue showed a significant difference between two groups, but this difference was not statistically significant. The amount of collagen in the connective tissues were different. Histologic observations showed that after using Oralmedic, some changes such as inflammation, scar formation, and fibrosis were observed in the surface of epithelium of the mucosa and connective tissues.
The important point in use of oral medications, in addition to changes in the surface epithelium of the mucosa, is deeper changes that can lead to important and sometimes problematic consequences.