TGF-β1 Gene Polymorphism at Position -800G /A and Systemic Lupus Erythematosus
Author(s):
Abstract:
Introduction
Systemic lupus erythematosus (SLE) is a chronic systemic inflammatory autoimmune disease characterized by a breakdown of self-tolerance. Transforming growth factor-β1 is a cytokine produced by both immune and non immune cells, and it has a wide operating range. human TGF-β1 gene is located on chromosome 19q13 . The aim of this study was investigating the TGF-β1 Gene Polymorphism at Position -800G /A and Systemic Lupus Erythematosus the possible difference in two promoter polymorphisms of the transforming growth factor-β1 (TGF-β1) gene (-800G / A, -509C / T).Methods
In this case - control study, a total of 150 patients with SLE and 150 healthy subjects were examined. DNA was extracted by saluting out method and Single nucleotide Polymorphisms of the TGF-β1gene were analyzed by the PCR-RFLP method and the .Data were compared in both groups by using Pearsons chi-square and Hardy-weinberg equilibrium test.Results
There was a statistically significant difference in AA genotype and A allele frequency distributions between SLE patients and the control group for the -800G / A polymorphism of the TGF-β1 gene (P Conclusion
The results of our study indicate that TGF-β1 gene promoter polymorphisms at positions -800 G/A maybe discuss susceptibility to SLE in southern Iranian patients.Keywords:
SLE , TGF , β1 , Genotype , Polymorphism
Language:
Persian
Published:
Journal of Shaeed Sdoughi University of Medical Sciences Yazd, Volume:24 Issue: 3, 2016
Pages:
251 to 260
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