Relationship between idiopathic hypercalciuria and urinary tract infection in children of 1-14 years of age

Urinary tract infection (UTI) is one of the most common causes of chronic renal failure of children. Therefore diagnosis of predisposing factors have an important role to prevent renal damage. This Study was performed to investigate the association between idiopathic hypercalciuria and urinary tract infection in children 1-14 years of age admitted to Amiralmomenin hospital of Semnan (Iran).
This was a case-control study in which 75 children with UTI (without renal stone and urinary tract malformation) and a control group of 75 children without UTI were investigated. We measured random urine calcium to creatinine ratio in these children. In order to ruled out of secondary hypercalciuria, serum calcium, phosphor alkalene phosphatase, venous blood gases also were measured.
67 out of 150 patients (89.3%) were females and the rest were males. The mean (± SD) age of children with UTI were 3.83 ± 2.78 years and in control group were 3.88 ± 2.88 years which the difference was not significant (p = 0.907). Idiopathic hypercalciuria in 40% (n = 30) of children with UTI and 13.3% (n = 10) of children without UTI was found (P Based on results of this study, idiopathic hypercalciuria has a significant correlation with UTI in children and investigation of urinary calcium excretion in children with UTI is recommended.