Comparison of serum nesfatin-1 level in type 1 and 2 diabetic rats

Diabetes mellitus was induced, when the body doesn’t produce enough insulin (diabetes type 1) or is unable to use insulin properly (diabetes type 2)..In this study we compare serum nesfatin-1 level in type 1 and 2 diabetic rats.
18 male Wistar rats were divided randomly into 3 groups. Group1: control, Group2: diabetic type 1, Group3: diabetic type2. Diabetes type 1 was induced by a single injection of STZ (55 mg/kg) and diabetes type 2 was induced by STZ (60 mg/kg) and NA (110 mg/kg). FBG (fasting blood glucose), insulin, nesfatin-1were measured in all groups after 6 weeks.
nesfatin-1 levels were increased in diabetic rats to the control. It’s level in serum was significantly higher in type 2 compared to type 1 diabetic rats. Serum insulin and body weight were reduced significantly in diabetic rats compared to control and was lower significantly in type 1 than type 2 diabetic rats. . FBG were increased significantly in diabetic rats compared to control and it was higher in type 2 compered to type 1 diabetic rats significantly. (P Nesfatin-1 level in serum of type 2 diabetic rats was higher than type 1 maybe because of higher weight and less destruction of beta cells in type 2 diabetic rats.