The effect of aerobic training on cardiac expression of mir-126 in diabetic rats
Author(s):
Abstract:
Background
Aerobic training is well supported as a useful component of an exercise. One of the most common adaptations that occur in this type of training is creating new vessels and increased angiogenesis factors. Aerobic training can be effective on angiogenesis.The aim of this study was to investigate the effect of aerobic training on cardiac expression of mir-126 innormal and diabetic rats.
Methods
35 Rats divided to two categories, diabetic and non-diabetics rats. Then each category of diabetic and non diabetic animals divided to two groups: under training and nontraining.Cardiac muscle was removed and immediately placed into liquid nitrogen. Cardiac expression of mir-126 investigated in rat cardiac muscle using Real-time PCR. For data analysis, One-way ANOVA and post-hoc Tukeys test were used.Results
The study results showed diabetes significantly decreases cardiac expression ofmir126 and 8 weeks of aerobic training significantly increases cardiac expression of mir126
in healthy and diabetic rats.
Conclusion
It seems aerobic training can prevent negative effects of diabetes via angiogenic path. Thus, kindle regulatory rocesses by mir126 that via aerobic training are impressed, could be worthy strategy on development of new theraphy methods in diabetes treatment.Keywords:
Aerobic Training , Angiogenesis , VEGF , mir126 , Diabetes
Language:
Persian
Published:
Razi Journal of Medical Sciences, Volume:23 Issue: 7, 2016
Pages:
44 to 55
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