Effect of Hydro-Alcoholic Extract of Ginger Rhizome on Blood Factors in Acetaminophen-Induced Liver Toxicity in Mice

Background The research has shown that some plant extracts have protective effects on hepatocytes. This study examined the effects of ginger on hepatotoxicity. Administration of ginger can reduce blood glucose, triglycerides, cholesterol, antioxidant, blood pressure, and heart rate and it has anti-inflammatory effect.
Materials and Methods Thirty-six female NMRI mice were randomly divided into 6 groups. Group I as a control group received ethanol 20%. Group II, as an intoxicated control group treated with acetaminophen (500 mg/kg BW). In groups III and IV, extract of ginger rhizome (GR) 20 and 40 mg/kg BW was administered, respectively. In the groups V and VI, extract of ginger 20 and 40 mg/kg BW along with acetaminophen (500 mg/kg BW) was administered, respectively. At the end of trial, blood samples were taken. SAS 2001 software was used for data analysis with significant level set at PResults Ginger extract with the dosages of 20 and 40 mg/kg BW reduced serum glucose, cholesterol, and triglyceride significantly.
Conclusion Ginger extract has the potential for decreasing glucose and fat and prevents liver damages. These results obviously need further investigation.