Effects of Pimozide on Physiology of Reproduction in Adult Male Rat

Inroduction & Pimozide is an antipsychotic with neuroleptic properties that has been found to be useful in the management of chronic schizophrenic patients , mania and hypomania. This drug blocks dopamine receptors. In this research the effect of pimozide were studied on pituitary gonad axis function, the concentration of testosterone , FSH and LH level and testis histological changes.
The present study was done on 50 male rats wistar strain that divided to 5 groups of 10 animal, including: Control, sham (received normal saline as a solvent) and three pimozide (1,2,4 mg/ kg) received the experimental groups. The drug were administered for 30 days orally and blood samples were taken from the rats and serum concentrations of testosterone, FSH and LH were measured by RIA method. Histological changes were studied among experimental, control and sham groups. The results were evaluated by using SPSS software and ANOVA tests.
The results showed that 4 mg/ kg dose of pimozide reduced testosterone. The level of FSH and LH were increased (P
Conclusion So in general we can say that high doses of pimozide decreases the concentration of testosterone level and the number of spermatogenic cells exception sertoli.