The effect of 12 weeks vitamin E supplemention and aerobic training on liver enzymes of non-alcoholic steatohepatitis patients

Non-alcoholic steatohepatitis is a part of broad spectrum of chronic non-alcoholic fatty liver disease. The aim of present study was to evaluate the effect of 12 weeks vitamin E supplementation and aerobic training on liver enzymes level of non-alcoholic steatohepatitis Patients (NASH).
In the present quasi-experimental study, 30 NASH patients, ages 25-50 years participated in the study , and were divided into three groups of vitamin E (n=10), aerobic training (n=10) and combination (aerobic training plus vitamin E, n=10) randomly. Vitamin E Supplementation and aerobic trainingcombination groups, consumed 400 IU per day of Vitamin E Supplementation. aerobic training and combination groups performed progressive aerobic exercise 3 times a week for 12 weeks. Data were evaluated usingindepended t-test and One-way ANOVA (pretest-posttest design) and post hoc test of Sheffee at a significance level of p≤0.05.
there was a significant within group difference in ALT in supplementation(P=0.0001), aerobic training(P=0001) and combination (P=0.001) groups. There was a significant pre – post training difference in AST in supplementation(P=0.001), aerobic training(P=0.001) and combination (P=0.002) groups but there was no significant within group difference in ALP(P>0.05). between group comparison indicated significant difference regarding ALP between supplementation and aerobic traing groups and also combination and supplementation groups(P=0.001). But thee was no significant between group difference regarding ALT and AST(P>0.05).
The results of this study showed that vitamin E supplementation and aerobic training can improve non-alcoholic steatohepatitis Patients (NASH).