Octreotide use in the Treatment of Recurrent Hypoglycemia in a Suicidal Patient with Insulin and Glibenclamide

Hypoglycemia attack a clinical case of sulfonylureas toxicity in patients considered. Given the vulnerability of the brain in the long hypoglycemia in plasma glucose concentrations have returned to normal as quickly as possible, as well as the recurrence must be prevented.
Case Report: Fifty -year-old female patient without past history of diabetes with decreased level of consciousness by emergency medicine serves (EMS) administration of naloxone was taken to the hospital. The patient on admission GCS of 12, the patient's blood sugar and potassium, respectively, 40 and 2.8 mg per dl, the patient was alert with infusion of 50% glucose. The patients in the first and second days despite treatment with hypertonic dextrose infusion and oral diet with relapse of hypoglycemia as loss of consciousness, sweating and was restless. Because of recurrent hypoglycemia, the third day, Octreotide was administered at a dose of 50 mg subcutaneously every 12 hours. Number of relapses of hypoglycemia was reduced. The fourth day, Octreotide were changed to 50 mg every 6 hours and hypoglycemia attacks stopped.
Discussion and Typically in the treatment of hypoglycemia caused by poisoning oral anti-diabetes drugs such as Glibenclamide and insulin the Hypertonic glucose injection and is used for patients starting oral feeding. But it seems that Octreotide listed on the timing of the dose to treat patients with acute poisoning with sulfonylurea, hypoglycemia with frequent recurrences are to be effective.