Effect of Ellagic Acid on Motor and Memory Disorders Induced by 6-OHDA in Male Rats

Parkinson's disease is a prevalent neuropathological disorder which is induced due to the degeneration of dopaminergic neurons of the dense part of sabestantia nigra. Oxidative stress is regarded as a main factor of this disease which causes death of neurons. Considering the protective antioxidative property of ellagic acid, the aim of the present study was to investigate effect of ellagic acid on motor disorders and memory of animal model of Parkinson's disease. 40 male rats were divided into 5 groups. To create an animal model, the rats received 6-OHDA neural poison with dose of 8 µg in 2 µl of normal saline solution with 0.01% of ascorbic acid inside medial forebrain bundle (MFB) on the left side of the brain. The treatment groups received ellagic acid with doses of 10, 25, and 50 mg/kg for 14 days as gastric gavage and tests were conducted on the rats one day after the last gavage. ellagic acid improves Motor and memory disorders motor disorders and memory resulting from Parkinson's disease Particularly at doses 50 mg/kg. Considering the present findings, it can be suggested that ellagic acid has a protective effect on 6-OHDA in the experimental model of Parkinson's disease.