Assessment of the antinociceptive, antiinflammatory and acute toxicity effects of Ducrosia anethifolia essential oil in mice

Ducrosia anethifolia (Moshgak) is one of the most important herbs used in traditional medicine for treatment of anxiety and insomnia. The aim of this study was to evaluate the anti-inflammatory and analgesic effects of Ducrosia anethifolia leaf essential oil (DAEO) in male mice.
Material and This experimental study included 84 male mice. For evaluation of pain, we used pain assessment tests (writhing, tail-flick and formalin) and animals were divided into control group and experimental groups. The experimental groups treated with the essential oil (30, 100 and 300mg/kg), morphine, and naloxone plus 300 mg/kg of essential oil. We used Xylene test for evaluation of anti-inflammatory effect, and divided the animals into 5 groups: control, DAEO (10, 50, and 100 mg kg) and dexamethasone.
In tail-flick and writhing tests, application of a dose of 300 mg/kg of DAEO showed a significant analgesic effect (P Intraperitoneal administration of DAEO can produce analgesic and anti-inflammatory effects.