Evaluation of Serum Biochemical and Histopathological Changes in Mice-Diabetic Kidney Followed by Simultaneous Injection of Nanoparticles of Zinc oxide and Thiamine

In this study, the effects of zinc oxide nanoparticles (ZnO NPs) and thiamine on the blood biochemical markers and kidney histopathological changes after experimental diabetes in mice was investigated.
For this purpose, 56 mice were randomly divided into 8 groups of 7 each. Two groups of animals as controls (A) and thiamine (G) were considered. Other groups were diabetic by alloxan at a dose of 180 mg/kg. Group B mice were considered as diabetic group. To diabetic mice into Group C and D , ZnO NPs in concentrations of 0.1 and 0.5 mg/kg were intraperitoneally injected. Groups E and F; to these groups of diabetic mice, ZnO NPs in concentration of 0.1 and 0.5 mg/kg along with thiamin (30 mg/l) was injected. ZnO NPs in concentration of 0.1 was injected to group H mice. Changes in renal tissue along with some biochemical parameters were measured.
The results showed that diabetes induced changes in some of the serum biochemical factors (GGT, BUN and creatinine) in rats (p Treatment of the diabetes mice by ZnO NPs and thiamine improves renal histopathologic structure and blood biochemistry levels.