The Effect of Trichostatin A on Working Memory and Serum Bcl-2 Level in Hypoxic-Ischemia Rat Model

Cerebral ischemia, occurs when a blood clot has occluded a brain artery, is the third leading cause of mortality in the Western world. The present study was aimed to investigate the effects of Trichostatin A (TSA), a histone deacetylase inhibitor, on cognitive deficits and serum Bcl-2 level in an animal model of hypoxia-ischemia rat model (HI).
Thirty male Sprague dawley rats were randomly divided into the healthy control, HI䦩抝 and HI䴠 groups. The rats were suffered from the right common carotid artery ligation and 8% oxygen for 5 min to produce HI model. Two days after induction of ischemia, HI䴠 group received intraperitoneally TSA for 5 days. The Y maze test was used to assess the working memory. The ELISA test was performed to measure the serum Bcl-2 level.
The results showed amelioration of working memory in HI䴠 group compared to HI䦩抝 rats. In addition, a significant difference in the serum level of Bcl-2 was observed between HI䴠 and HI䦩抝 groups.
The data suggested TSA as a potential treatment for amelioration of cognitive deficits after brain ischemia.