Therapeutic effect of aerobic training on cross-linked telopeptides of type I collagen (CTX) as bone resorption indicative in obese male with mild to moderate asthma

Long-term usage of inhaled corticosteroids is associated with osteoporosis in asthma patients. The objective of present study was to determine the effect of long term aerobic training on cross-linked telopeptides of type I collagen (CTX) as bone resorption index and serum calcium in corticosteroid-treated asthmatic middle-aged patients.
For this purpose, Twenty-four obese males with mild to moderate asthma treated with inhaled corticosteroids (ICS) matched for age 38 ± 7 year and BMI 31.5 ± 3.5 kg/m2 were divided randomly into exercise (aerobic training) and control (no training) groups. Exercise subjects performed supervised aerobic training for 3 months aerobic training, 3 sessions (45-60 min) per week at 55-75 (%) of maximal heart rate. Pre and post-training fasting blood samples were collected for measure CTX and calcium of 2 groups. Independent T test used to compare pretest data between 2 groups and Paired sample T test used to determine the intra-group change of each variable. The level of significance was set at P Aerobic intervention resulted in significant decrease in body weight, BMI and body fat percentage (p A long-term aerobic intervention can induce favorable effect on bone turnover by improved bone resorption indicatives in asthma patients. Based on this finding, regular aerobic training is purposed to prevent and decrease osteoporosis intensity in corticosteroid-treated asthmatic patients.