Comparing the Acute and Chronic Effects of Metformin on Serum Oxidative Stress factors in Streptozotocin-Induced Alzheimeric Male Rats
Author(s):
Abstract:
Introduction
Studies have indicated that metformine has different effects on learning and memory. In this study, both acute and chronic therapeutic effects of metformin on memory retrieval and some serum oxidative stress factors in Streptozotocin -induced Alzheimeric male rats were investigated.Methods
In this experimental study, 48 rats were divided into six groups (n=8) as follows: saline - saline, streptozotocin - saline, and streptozotocin - metformine (once, one week, three weeks and eleven weeks). Intracerebroventricular administrations of streptozotocin (3mg/kg) were done at the first and third day of the surgery. Intraperitoneally administrations of saline (ml/kg) or metformin (200mg/kg) was started one day before the surgery and continued until the end of the care period. The animals memory was evaluated through passive avoidance learning; blood serums were used to measure the levels of malondialdehyde, assessment of Ferric Reducing Ability of Plasma (FRAP), levels of superoxide dismutase and catalase enzymes.Results
Streptozotocin (STZ) significantly reduced the memory retrieval and the levels of FRAP, superoxide dismutase and catalase enzymes and it significantly increased the level of malondialdehyde compared to the control group (p0/05).Conclusion
It seems that administration of acute and chronic metformin has different effects on the memory retrieval that it may be due to the effect of chronic metformin in increasing the level of oxidative stress factors in serum.Keywords:
Language:
Persian
Published:
Journal of Shaeed Sdoughi University of Medical Sciences Yazd, Volume:25 Issue: 3, 2017
Pages:
206 to 221
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