Anti-proliferative and apoptotic effects of Lovastatin on K562 Erthromyloidy cancer cell line
Author(s):
Abstract:
Background And Objective
Lovastatin is a HMG-CoA reductase inhibitor and used for the treatment of hypercholesterolemia. Inhibition of HMG-CoA reductase results in inhibiting the activity of the Ras proto-oncogene that has mutations in most cancers. This study was done to determine the Anti-proliferative and apoptotic effects of Lovastatin on K562 Erthromyloidy cancer cell line.Methods
The K562 Erthromyloidy cancer cell line were cultured and treated with different concentrations of lovastatin. Their antitumor effect on K562 cells were assessed via MTT assay after 72 hours. Hoechst (33342) staining and DNA electrophoresis were used for study of apoptosis.Results
Lovastatin had antitumor effect on K562 Erthromyloidy cancer cell line and this effect increased by incease of time and concentration.The maximum inhibitory effect was 59% in higher concentration (100 µM) and 72 hours after the treatment. Reduced cell growth at 24 and 48 hours after treatment was 24% and 43%, respectively. Lovastatin significantly inhibited K562 cell growth (PConclusion
This study showed that lovastatin has antitumor effect on K562 Erthromyloidy cancer cell line. Language:
Persian
Published:
Journal of Gorgan University of Medical Sciences, Volume:19 Issue: 3, 2017
Pages:
52 to 59
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