Assessment of the cytotoxicity and in vivo anti-Plasmodial activity of ethanol and dichloromethane extracts of four different Iraninan propolis
Author(s):
Abstract:
Background
The emergence of antimalarial drug resistance is one of the great problems of malaria control and elimination of worldwide. In order to overcome anti-malarial drug resistance, cytotoxicity and in vivo anti-Plasmodiumal activity of four different Iranian propolis were investigated.Materials And Methods
Four Iranian propolis samples were collected from four different regions of Iran and extracted by %70 ethanol and dichloromethane. The cytotoxicity of ethanolic and dichloromethane extract of propolis, using L969 fibroblast cell lines, were evaluated by MTT assay. The in vitro anti-Plasmodial activities of the propolis samples on BALB/c mice were assayed.Results
The cytotoxicity results showed that ethanol and dichloromethane extracts of four Iranian propolis samples at doses of 25, 50, 100 and 200 µg/ml were non-toxic (PConclusion
Considering the drug resistance of P. falciparum to conventional medicine and its dangers, and the emergence of development cheap and safe anti-malaria drugs to control and eliminate programs. Further investigation on Iranian propolis as safe and anti-malarial drug is recommended.Keywords:
Language:
Persian
Published:
Yafteh, Volume:19 Issue: 2, 2017
Pages:
115 to 125
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