Effects of Pomegranate uice (Punica granatum)on the Pituitary Thyroid Hormones in Adult Male Rats

Inroduction & Pomegranate juice contains a variety of chemical compounds that have properties such as anti-obesity, diabetes, anti-cancer, anti-hepatotoxicity, lowering blood sugar and cholesterol, and therefore this study was performed aimed to investigate effects of pomegranate juice on the plasma concentration of hormones in the pituitary-thyroid axis in adult male rats.
Material and 50 male rats who weighs 210 to 200 grams were divided into 8 pieces included a control group(no treatment), control group (treated with distilled water) and experimental group receiving Pomegranate juice 3, 6 and 9 ml daily. All prescriptions were performed by gavage for 10 days. At the end of the period after weighing animals and phlebotomizing, and so plasma producing, plasma levels of hormones TSH, T4, T3 was measured by ELISA method and the results were analyzed by ANOVA and T tests. The significant difference in the data P ≤0.05 was considered.
The results of the study showed that pomegranate juice has no the significant effects on body weight, but the group receiving dose of 3 mL with TSH concentrations has a significant increase, but in the dose of 9 ml with concentration t3 and t4 in all groups has a significant decrease at the P ≤0.05.
The results showed that pomegranate juice had no effects on the rats’ weight but in the form of dose-dependent was caused to increase the plasma levels of the hormone TSH and to decrease t3 and t4 hormones.