Synthesis of biodegradable and self-assembled anionic nano - carrier: Novel approach for improvement of Curcumin- delivery to bone tumors cells & Mathematical modeling of drug-release kinetic
Author(s):
Abstract:
Aim and
Material and
Background
Osteosarcoma is the most common cancer among adolescents. Curcumin has induction sensitivity effect to cancer cells against chemotherapy and anti-tumor. In present study, the sustained- release niosomal carrier containing Curcumin were prepared to improve anti-cancer effect of Curcumin against osteosarcoma.Material and
Methods
Anionic prepared niosomal vesicle are contained 70 % (molar ratio) of Tween 60, 30% (molar ratio) of Cholesterol in the presence DSPE-mPEG 200. Prepared nano-particle was characterized and the cytotoxicity of free Curcumin was evaluated in comparing of niosomal Curcumin on MG-63 cell line using MTT assay. A suitable kinetic model was also suggested in order to predicting drug release.Results
Results showed the size diameter, encapsulation efficiency, zeta potential and poly disparity index are 242 nm, 95.2%, -38 mv and 0.17, respectively. Prepared niosomal particles are controlled-release and the cumulative release is 43.87 % during 96 hours. Peppas model indicates good confirmation with experimental results. Cytotoxicity results showed 0.9-fols improvement in killing cells efficiency for niosomal Curcumin in comparing free Curcumin.Conclusion
The niosomal carrier containing Curcumin is sustained-release, mono-disperse with high encapsulation efficiency and suitable size diameter. The results of surface charge evaluation confirmed that prepared nano-carrier is anionic and it can effectively be used in the treatment of bone cancer. Keywords:
Language:
Persian
Published:
New Cellular & Molecular Biotechnology Journal, Volume:7 Issue: 27, 2017
Pages:
77 to 84
magiran.com/p1755239
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یکساله به مبلغ 1,390,000ريال میتوانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
- حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران میشود.
- پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانههای چاپی و دیجیتال را به کاربر نمیدهد.
In order to view content subscription is required
Personal subscription
Subscribe magiran.com for 70 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!