Role of phosphor and GAS-6 in inflammation in hemodialysis patients in Tabriz, Iran
Author(s):
Article Type:
Research/Original Article (بدون رتبه معتبر)
Abstract:
Introduction
Inflammation is recognized in up to 50% of chronic kidney disease (CKD) patients, being a common feature of advanced renal disease and crucial mediator of vascularcalcification which may be relevant in CKD. This study was aimed at evaluating the role ofGrowth arrest-specific 6 (Plasma GAS-6) and mineral metabolism abnormalities inhemodialysis (HD) patients.Methods
We enrolled a total of 92 adults including 46 (28 males and 18 females) clinicallystable HD patients and 46 (23 males and 23 females) patients with normal kidney as control group. Plasma GAS-6, Interleukin 6 (IL-6), and high sensitivity C-reactive protein (hsCRP)concentration and biochemical alteration were quantified; as biochemical factors, GAS-6,IL-6, and hsCRP levels were determined by standard methods.Results
Levels of GAS-6 were significantly increased in HD patients compared with normalcontrols (P Conclusion
Elevated serum P and GAS-6 might play a role in the development ofinflammation in CKD patients. Although our study shows that GAS-6 is directly associated with IL-6 and phosphor with hsCRP, their direct role in vascular calcification and type of theirrelationships need further studies in the future. Language:
English
Published:
Journal of Analytical Research in Clinical Medicine, Volume:2 Issue: 1, Winter 2014
Pages:
18 to 24
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