The effect of ethanolic extract of Allium Saralicum R.M. Fritsch on diabetic hepatopathy in male mice

Using medicinal plants is the oldest way to treat the different diseases. Various plants are recommended for the treatment of diabetic patients. Hepatoprotective and antidiabetic effects of the ethanolic extract of Allium Saralicum R.M. Fritsch (ASRMF) on diabetic male mice has been assessed in the present study.
In this experimental study, 35 adult male mice were used. Diabetes was induced by administration of 60 mg/kg of streptozotocin intraperitoneally in 28 mice and they were divided into 5 groups of 7 mice each. The positive control group (non-treated diabetic) received normal saline and treatment groups received glibenclamide at a dose of 0.5 mg/kg and 200 and 400 μg/kg of ethanolic extract of ASRMF through gavage for 15 days. Also, one group considered as negative control (non- diabetic). On the last day, serum levels of glucose and AST (aspartate aminotransferase), ALT (alanine aminotransferase), and ALP (alkaline phosphatase) enzymes were measured. After preparation of tissue sections and staining, total volume of the liver, hepatocytes, sinusoids, portal vein, central vein, hepatic arteries and bile ducts were estimated.
The increased levels of blood glucose and AST and ALP enzymes were significantly decreased (P Ethanolic extract of ASRMF can regulate the levels of blood glucose and AST and ALP enzymes but can not inhibit hepatic damages in streptozotocin-induced diabetic mice.