Study of Matrix Metalloproteinase -1 Polymorphism and Susceptibility to Bladder Cancer

Matrix metalloproteinase-1 with the destruction of the basement membrane and extracellular matrix not only facilitates the spread of cancer cells, but also with the release of growth factors and angiogenesis plays a key role in cancer cell survival and nutrition. The purpose of this study was to recognize the relation between the polymorphism of Matrix metalloproteinase-1 gene and risk of bladder cancer.
This case-control study included 157 patients with bladder cancer and 143 healthy controls who were age-matched. First, DNA extraction from peripheral blood and then PCR was performed using specific primers. Then, RFLP method was used to evaluate the MMP-1 (-1607) polymorphism.
There was no significant difference between the frequency of 1G/1G, 2G/2G allels (P˃0.05). There was no association between polymorphism and susceptibility to bladder cancer [OR:1.23, 95%CI (0.67-2.28),P=0.49].
Due to the lack of association between MMP-1 polymorphism (-1607) and the risk of bladder- cancer, it is suggested that other polymorphisms of the matrix metalloproteinase-1 gene will be investigated