The Extract of Lamium album and Urtica dioica Increase Serum Insulin-Like Growth Factor 1 Level in Streptozotocin-Induced Diabetic Rats
Author(s):
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background
Diabetes mellitus is defined by hyperglycemia. Antidiabetic effects of Urtica dioica have been shown. Lamium album or nonstinging nettle is known to have useful impacts such as antioxidant and cytoprotective properties.Objectives
The aim of the present study was to evaluate the serum concentration of insulin-like growth factor 1 (IGF-1) in diabetic rats given U. dioica and L. album extracts to distinguish any relationship between IGF-1 level and these plant extracts administration.Methods
In this experimental study, 32 male rats divided into four groups; normal, diabetic, diabetic treated with U. dioica (100 mg/kg/daily), diabetic treated with L. album (100 mg/kg/daily) for 28 days. Fasting blood sugar (FBS) and IGF-1 concentrations were measured. One way ANOVA followed by the Tukey post hoc test was used for comparison between groups. In each group, FBS level among different times was compared using repeated measure ANOVA. Analysis was done using SPSS software version 22.Results
FBS level significantly increased in diabetic rats compared with control rats (P Conclusions
L. album and U. dioica might increase the level of serum IGF-1 in diabetes; with regard to insulin like activity of IGF-1, this might be viewed as a further support of positive influence of these plant extracts on this disease.Keywords:
Language:
English
Published:
Zahedan Journal of Research in Medical Sciences, Volume:19 Issue: 12, Dec 2017
Page:
5
magiran.com/p1787055
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یکساله به مبلغ 1,390,000ريال میتوانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
- حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران میشود.
- پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانههای چاپی و دیجیتال را به کاربر نمیدهد.
In order to view content subscription is required
Personal subscription
Subscribe magiran.com for 70 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!