Comparison the Effects of Trigonella foenum-graecum L Seed Extract and Cordia myxa Fruit Extract on Diabetes-Induced Memory Impairment in Rats

Fenugreek (Trigonella foenum-graecum L) and Cordia myxa are widely used as antidiabetic herbal drugs in Iranian Traditional Medicine. We compared the effects of Trigonella foenum graecum seed aqueous extract (TE) with Cordia myxa fruit aqueous extract (CE) on diabetes-induced cognitive dysfunction through the use of passive avoidance learning (PAL) and memory task. We also determined the level of brain lipid peroxidation as a possible mechanism. In this experimental study, rats were randomly allocated into four groups (n=12/group) as the following: Group 1: Healthy control rats; Group 2: Diabetic control rats; Group 3: diabetic rats that received TE (870 mg/kg BW) for 30 days; Group 4: diabetic rats that received CE (500 mg/kg BW) for 30 days. Diabetes was induced by alloxan (120 mg/kg BW ip).
Diabetes caused cognition deficits in passive avoidance learning and memory task. Cordia myxa fruit extract and Trigonella foenum graecum seeds extract significantly reduced serum blood glucose (P Aqueous extract of fenugreek seeds is more effective in preventing diabetes-induced lipid peroxidation and memory loss compared to aqueous extract of Cordia myxa fruit. :