Investigation protective effects of vitamin E against mobile radiations induced histological alterations and oxidative stress in rat's brain
Abstract:
Introduction
It has been shown that mobile radiations (MRs) have detrimental effects on brain histoarchitecture and vitamin E as a powerful antioxidant can exhibit neuroprotective effects. This study was carried out to evaluate the protective effects of vitamin E against MRs-induced histological changes in rat brain.
Methods
Adult female Wistar rats were randomly categorized into 4 groups (n₌6), including untreated control, experimental group1 (14 days exposure to mobile calls, 12 times every day and each time for 10 minutes by Huawei H30–U10 cell phone and then, sampling on day 15), experimental group2 (14 days treatment and then, sampling after 40 days) and experimental group3 (radiation vitamin E 100 mg/kg intramuscularly before MRs exposure).
Results
MRS-treatedrats showed significant reduction in body weight with an increase in brain relative weight. Moreover, MRS resulted in oxidative stress in brain tissue as well as increase in numbers of neurons with pyknotic nuclei in rats hippocampus. Interestingly, vitamin E co-administration led to oxidative stress suppression in brain tissue and nuclear pyknosis reduction in rats hippocampus.
Conclusion
Vitamin E can attenuate MRs- induced histological alterations and oxidative stress in rat hippocampus probably due to antioxidant activities.
Article Type:
Research/Original Article
Language:
Persian
Published:
Journal of Shaeed Sdoughi University of Medical Sciences Yazd, Volume:25 Issue:10, 2018
Pages:
828 - 842
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