THE CROSS-SECTIONAL INVESTIGATION OF THE ASSOCIATION BETWEEN ADIPOKINES OMENTIN-1, VASPIN, AND RETINOL BINDING PROTEIN-4 WITH BODY COMPOSITION INDICES AND METABOLIC STATUS OF WOMEN

The adipokines omentin-1, vaspin, and retinol binding protein-4 (RBP-4) are mediators of body composition and adipose tissue that contribute to metabolic changes caused by obesity. The aim of this study was to determine the association between serum levels of these adipokines with body composition indices and metabolic status in different phenotypes of body size.
In the present cross-sectional study, a total of 350 women, including 127 metabolically healthy (MH) subjects and 223 metabolically unhealthy (MUH) subjects participated. The subjects were considered as MH in the presence of at least 4 of the five following metabolic indices: TG ≤ 1.70 mmol/L, LDL-C≤ 2.60 mmol /L, TC≤ 5.20 mmol /L, HDL-C≥1.30, and HOMA-IR≤ 1.95; otherwise subjects were considered as MUH.
The results showed that serum levels of omentin-1 have a significant positive association with MHS (OR = 1.04, p Serum levels of adipokines may be an appropriate predictor for metabolically healthy status. Further studies in this field can reveal possible mechanisms.