The Investigation of Frequency and Antibiotic Resistance Pattern of Escherichia coli and Klebsiella pneumoniae Isolated From Urinary Tract Infection in Outpatients Referred to Amiralmomenin Ali Hospital in Gerash City in 2017: A Short Report

Urinary tract infection (UTI) is the presence of pathogens in the urinary tract. Escherichia coli and Klebsiella pneumoniae are the most common bacteria responsible for UTI. Due to the variety of antibiotic resistance mechanisms, treatment of these infections has been difficult, therefore, selection of appropriate antibiotic has an effective role in controlling and improving the infection. The present study aimed to determine the frequency and antimicrobial resistance patterns in Escherichia coli and Klebsiella pneumoniae strains isolated from outpatients with UTI referred to Amiralmomenin Ali hospital in Gerash city.

This cross-sectional study was performed on urine specimens of 1300 outpatients referred to Amiralmomenin Ali hospital in Grash, during a six-month period from April to September 2017. Strains were identified using biochemical tests and differential cultivation environments. The antibiotic resistance pattern of strains was investigated by Kirby-Bauer method. Chi-square test was used for data analysis.

Among 1300 urine samples, 247 samples (19%) were positive for bacterial growth. 148 urine samples (11.3%) were positive for Escherichia coli and Klebsiella pneumoniae, among them 108 Escherichia coli strains (72.97%) and 40 Klebsiella pneumoniae strains (27.03%) were isolated. The most and the least antibiotic resistance in Escherichia coli was to Nalidixic Acid (59.3%) and Nitrofurantoin (22.2%), respectively. For Klebsiella pneumoniae strains, the most and the least antibiotic resistance was observed to Nitrofurantoin (67.5%) and Ciprofloxacin (25%), respectively.

The UTI caused by Escherichia coli is more common in comparison with Klebsiella pneumoniae. For the initial treatment of urinary tract infections, the use of Nitrofurantoin, Ciprofloxacin, and Cotrimoxazole antibiotics is recommended.