The effect of oil extract of Portulaca oleracea seeds on insulin resistance indices in mice

Recently, drugs of natural origin have been considered for treatment of diabetes. Purslane (Portulaca oleracea) is an important endemic Iranian medicinal plant. The aim of this study was to investigate the effect of oil extract of purslane seeds on insulin resistance indices in mice. In this study 30 adult mice were divided into five groups of six: (1) Negative control (non- diabetic), (2) positive control (diabetic), (3) purslane seeds extract control (non-diabetic), (4) 150 (mg/kg) oil extract of purslane seeds (diabetic) and (5) 300 (mg/kg) oil extract of purslane seeds (diabetic). Pursulane extract was gavaged to groups 3, 4 and 5 for one month. After this period, diabetes induction was performed by injection of streptozocin in 2nd, 4th and 5th groups. After two months, blood samples were taken and the indices were measured and analyzed statistically. The overall period of the study was 3 months. Oil extract of purslane seeds decreased serum glucose significantly in diabetic groups in comparison to positive diabetic group (p