Effect of zinc chloride on anxiety and deppresive behaviors of rats, in ovarectomized peri-pubertaly

Previous studies have shown that the anxiolytic effects of different zinc chloride in male and female rats is Castration post- pubertaly. This study, the effect of zinc chloride on anxiety and deppresive behaviors of rats, in ovarectomized peri-pubertaly was investigated. In this experiment, fifty female rats were ovariectomized at postnatal day 21-22 and then on postnatal day 75, different doses of zinc chloride (0, 5, 10 and 20 mg/kg; IP) were administered 30 min before the elevated plus maze and forced swimming test. Ovarectomized significantly decreased the time spent in the open arms in ovarectomized rats compared to the sham group (p