Regeneration effect of Saffron on the liver damaged with paraquat in male mice
Message:
Abstract:
Background And Objective
Paraquat is a common agricultural herbicide that is a strong stimulus in superoxide anions foundation. Due to the adverse effects of the free radicals, the anti oxidant compounds such as Saffron seem necessary as antioxidants and removing the free radicals. The aim of this study was to evaluate the regeneration effect of Saffron on the liver damaged with paraquat in male mice.
Methods
In this experimental study, 36 male mice were randomly allocated into 6 groups. Animals in group one were received normal food, water and corn oil. Secound and third groups of mice were treated at a dose of 20, 40 mg/kg/bw paraquat, respectively. Animals in the fourth group were received Saffron at a dose of 80 mg/kg/bw. Animals in fifth and sixth two groups were treated with paraquat treated at a dose of 20, 40 mg/kg/bw and Saffron (80 mg/kg/bw), orally, per day. At the end of 30 days the mice were anesthesia and blood samples were prepared for measurement of AST and ALT in sera and livers were removed for measurment of MDA, FRAP, katalaze concentration and half of liver was transfer to formaline for histopathological study.
Results
Cell necrosis and inflammation was found in the liver of mice treated with paraquat, also the level of AST, ALT and MDA was significantly increased in compared to controls (P
Conclusion
Saffron (80 mg/kg/bw, orally) improves liver dysfunction in mice exposed with paraquat.
Article Type:
Research/Original Article
Language:
Persian
Published:
Journal of Gorgan University of Medical Sciences, Volume:20 Issue:2, 2018
Pages:
55 - 61
magiran.com/p1837346  
روش‌های دسترسی به متن این مطلب
اشتراک شخصی
در سایت عضو شوید و هزینه اشتراک یک‌ساله سایت به مبلغ 300,000ريال را پرداخت کنید. همزمان با برقراری دوره اشتراک بسته دانلود 100 مطلب نیز برای شما فعال خواهد شد!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی همه کاربران به متن مطالب خریداری نمایند!