Investigating the Effect of Mixed Surfactants with Different HLBs on the Properties of Solid Lipid Nanoparticle of Spironolactone

Background and This study investigated the effect of different HLBs on these nanoparticles using spironolactone solid lipid nanoparticles.
The spironolactone loaded SLN was prepared by emulsion/solvent evaporation technique followed by ultrasonication. In this study, Palmitic acid was used as carrier. Different weight ratio of drug, carrier, Span60 and Tween80 were selected. Different formulations were prepared with different HLBs. Nanoparticle properties like particle size, polydispersity index, zeta potential and entrapment efficiency were investigated. Optimum formulation was chosen for evaluation of drug release and other properties of nanoparticles by DSC and FT-IR spectroscopy.
Increasing lipid concentration resulted in consequent increase entrapment efficiency and the size. Also, the F1-F9 formulations showed that Zeta potential was in an acceptable range, and only reduce in HLB in F4 was accompanied with decreasing Zeta potential. Spironolactone was found to have a higher drug release rate in the SLN form. Information from the FT-IR spectroscopy and the DSC thermogram indicated effective entrapment of drug in the carrier.
spironolactone-SLNs provide a controlled and increased drug release rates. Spironolacton-SLN would provide high drug levels at the site of action, therefore, this product could be useful in topical drug delivery.