Evaluation of the protective effect of Nigella sativa oil on ovarian follicles in mice treated with silver nanoparticles
Author(s):
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Aim: the effect of Nigella sativa oil (NSO) as an efficient antioxidant on ovarian follicles following treatment with Silver Nanoparticles (SNP) in adult mice.
Material and
Material and
Methods
Twenty-four adult NMRI mice, weighing 27-30g were used in the present experiment. The animals were kept under optimum conditions of temperature (At 21± 2 ° C and ambient lighting conditions 12 hours of darkness and 12 hours of light) humidity and maintained on standard pellet diet with adequate water. They were divided into four groups of (six mice per group): control; Silver Nanoparticles (300 mg/kg/day, orally), Nigella sativa oil (5 ml/kg/day, orally) and finally Silver Nanoparticles plus Nigella sativa oil. After 30 days, the mice were sacrificed and the ovary tissues were separated. The results were analyzed using one-way ANOVA and Tukeys test, and the means were significantly different at PResults
The results of this study showed that, the mean total volume of ovary and the number of primordial, primary, secondary and graph follicles significantly decreased in the Silver Nanoparticles group compared with the control group (pConclusion
So it is not far-fetched that this oil has improved the factors in our study.Keywords:
Language:
Persian
Published:
Journal of Developmental Biology, Volume:10 Issue: 1, 2018
Pages:
11 to 19
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