Changes of ATP –binding cassette transporter type G8 gene expression subsequent eight weeks of quatic and dryland resistance training in middle-aged women’s Peripheral blood cells after coronary artery bypass grafting

Cardiac rehabilitation program aimed at reducing secondary risk factors and improving function in patients undergoing coronary artery bypass grafting run which finally may delay or reduce mortality patients. A key component of this program is exercise. The aim of this study was to evaluate the effect of aquatic and dryland training on ABCG8 gene expression in middle-aged women’s peripheral blood mononuclear cells after coronary artery bypass grafting. 30 middle-aged women with cardiovascular disease were divided into three groups including control, aquatic and dryland resistance training. The program lasted for eight weeks of resistance training (3 sessions per week/ 60 minutes per session) and started with 60% of 1RM. Fasting blood samples were taken from all participants 48 hours both prior to the beginning of the training program and after the last training session. ABCG8 relative gene expression was detected by Real-time PCR method. Repeated measures and paired t-test with a significance level of p≤ 0.05 were used to determine differences between and within groups. Repeated measures test showed a significant increase in the relative ABCG8 gene expression in both the aquatic and dryland training groups (P= 0.001). Moreover, paired-samples t-test showed a significant difference in aquatic and dryland training groups regarding ABCG8 gene expression (P= 0.001; P= 0.001). It can be concluded that both training programs on land and water training, increase ABCG8 gene expression in middle-aged women after coronary artery bypass and a possible reverse cholesterol transport process can be improved.