The effects of aerobic exercise in Sprague Dawley pregnant rats on BRCA1 and P53 gene expression of adult offspring breast tissue
Author(s):
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background and aims
Pregnancy is an important period in women life regarding different aspects including physical activity which may be effective on various health indices of offspring. One of the common and expanding women diseases is breast cancer and two of its related indices are BRCA1 and P53. Thus, the aim of present study was estimating the effect of aerobic training during pregnancy in pregnant rats on the expression of BRCA1 and P53 genes of their offspring’s breast tissue.
Methods
20 female Sprague Dawley rats were randomly divided into two groups of exercise during pregnancy (T) (221±9.9) and control (C) (223.8±12.8). The aerobic exercise training was performed immediately after observation of the vaginal plaque of approving pregnancy for21 days and 5 sessions per week with moderate intensity. About 2 to 3 days before delivery, their training program was terminated. Tissue sampling of Pairs 4, 5, and 6 of breast tissues in
8 weeks offspring rats was performed to evaluate the expression of BRCA1 and P53 gene. Data was analyzed using SPSS software and statistical tests of Shapiro-Wilk to control the distribution of data, and independent t-test for comparisons of between groups.
Results
Aerobic training with moderate intensity during pregnancy increased significantly mRNA of the BRCA1 gene (P=0.001), but there was no significant change in mRNA of the P53 (P=0.69).
Conclusion
Considering the effect of exercise during pregnancy on increasing BRCA1 gene expression in their offspring's and association of the gene with breast, it seems that moderate exercise during pregnancy can reduce the risk of breast cancer in childrenKeywords:
Language:
Persian
Published:
Journal of Shahrekord University of Medical Sciences, Volume:20 Issue: 5, 2018
Pages:
13 to 24
https://www.magiran.com/p1899875
مقالات دیگری از این نویسنده (گان)
-
The Effect of Short Term Time-Restricted Eating on Anthropometric Indices and Inflammation at Rest and Following Acute Exercise
Ahmadreza Dehghani, Mehdi Hemmat, *, Alireza Niknam, Mohammad Hemmatinafar, Mohammadhosein Ghasemi, Grant M Tinseley
International Journal of Nutrition Sciences, Sep 2024 -
Physiological Mechanisms of Exercise in Prevention and Treatment of Breast Cancer: A Review
Ahmadreza Dehghania, Mohammadhosein Ghasemia, *
Archives of Breast Cancer, Aug 2024 -
The Prevalence of Clostridium difficile and Clostridium perfringens in Minced and Ground Beef in Iran
Samaneh Hassani, Razzagh Mahmoudi *, Ata Kabudari, Peyman Ghajarbeygi, , Shagahyegh Moosavi, Saeed Shahsavari
Journal of Chemical Health Risks, Autumn 2022 -
Molecular Investigation of Resistance to Disinfectants in Acinetobacter Baumannii Isolates Collected From Qazvin Hospitals, Iran (2017)
Samaneh Keshavarz, Reza Shapouri, Narges Habibollah, Pourzereshki, Reza Bigverdi, *
Journal of Inflammatory Diseases,