Effect of Purslane (Portulaca oleracea )on CRP, TNF-Α, Hepatic Enzymes and Serum Nitrate in Rats with Experimental Allergic Encephalomyelitis

Inroduction & Objective: MS is an autoimmune disease that has a high prevalence in young people. Portulaca oleracea has useful materials such as mineral, organic acids, neurotransmitters, and antiinflammatory and antioxidant compounds. Therefore, in this study the protective effect Portulaca on inflammatory markers in rats with MS were studied. Material and Method: In this study of 18 female rats Lewis (180-200gr) was used. EAE was induced in 12 of them. Purslane extract at a dose 400mg/kg via the intraperitoneal was used for treatment. Serum levels of Nitrate, TNF-a and CRP were measured. Statistical analysis was performed using ANOVA.  In the group treated with the extract of purslane, Serum levels of Nitrate, TNF-a, CRP and Hepatic enzymes were reduced(P˂0.05). According to inflammatory properties of purslane, treatment Rats with EAE ,Can reduce inflammatory markers.